My research interests are in the effects environments and lifestyles have on human health. I am investigating this in the context of the aryl hydrocarbon receptor (AHR), a ligand-activated transcription factor that plays a role in xenobiotic metabolism, as well as other endogenous metabolic and immune functions. My projects in the Bradfield/Malecki lab utilize population health data and biorepository samples to evaluate differential AHR activation based on diet or environmental exposures. This AHR activation can then be compared to inflammatory and metabolic responses, providing a potential pathway for disease outcomes including obesity and cancers.
Bradfield Lab Webpage:
Malecki Lab Webpage: